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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHRNE All Species: 11.82
Human Site: S356 Identified Species: 28.89
UniProt: Q04844 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04844 NP_000071.1 493 54697 S356 L L P R L L G S P P P P E A P
Chimpanzee Pan troglodytes Q5IS76 494 56903 M355 L L P Q V L L M R W P L D K T
Rhesus Macaque Macaca mulatta XP_001097094 493 54680 S356 L L P R L L G S P P P P E A P
Dog Lupus familis XP_536608 492 54288 S356 Q L P S L L G S S A P P E A P
Cat Felis silvestris
Mouse Mus musculus P20782 493 54896 S356 L L P R L L G S S P P P E D P
Rat Rattus norvegicus P09660 494 54930 L356 L L P R L L G L S P P P E D P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P02713 514 58907 M358 L L P R Y L G M H M P E E A P
Frog Xenopus laevis P49580 504 57770 R358 L P Q F L H L R V E P C D E G
Zebra Danio Brachydanio rerio NP_996947 518 60339 L362 P R L L H M S L P V E D Q P V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P09478 567 64001 I355 I L P K L L C I E R P K K E E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.8 95.9 87 N.A. 88.6 87.6 N.A. N.A. 52.9 52.5 43.4 N.A. 32 N.A. N.A. N.A.
Protein Similarity: 100 54.2 97.3 92.6 N.A. 93 92.1 N.A. N.A. 68.2 71 61.7 N.A. 50.6 N.A. N.A. N.A.
P-Site Identity: 100 33.3 100 73.3 N.A. 86.6 80 N.A. N.A. 66.6 20 6.6 N.A. 33.3 N.A. N.A. N.A.
P-Site Similarity: 100 53.3 100 73.3 N.A. 86.6 80 N.A. N.A. 66.6 26.6 20 N.A. 53.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 10 0 0 0 40 0 % A
% Cys: 0 0 0 0 0 0 10 0 0 0 0 10 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 10 20 20 0 % D
% Glu: 0 0 0 0 0 0 0 0 10 10 10 10 60 20 10 % E
% Phe: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 60 0 0 0 0 0 0 0 10 % G
% His: 0 0 0 0 10 10 0 0 10 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 10 0 0 0 0 0 0 0 10 10 10 0 % K
% Leu: 70 80 10 10 70 80 20 20 0 0 0 10 0 0 0 % L
% Met: 0 0 0 0 0 10 0 20 0 10 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 10 80 0 0 0 0 0 30 40 90 50 0 10 60 % P
% Gln: 10 0 10 10 0 0 0 0 0 0 0 0 10 0 0 % Q
% Arg: 0 10 0 50 0 0 0 10 10 10 0 0 0 0 0 % R
% Ser: 0 0 0 10 0 0 10 40 30 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % T
% Val: 0 0 0 0 10 0 0 0 10 10 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _